Diabetes and Cancer

Glutamate Dehydrogenase (GDH) catalyzes the oxidative conversion of glutamate to alpha ketoglutarate and ammonium supplying the TCA cycle with intermediates in support of anaplerosis (Figure 1 Rxn1). Conversely GDH catalyzes the reductive amination of alpha ketoglutarate and ammonium producing glutamate when the TCA cycle pool is filled. The net GDH flux resulting from these bidirectional fluxes can be obtained from the conversion of either 15N labeled...

Skin cancer represents a major, and growing, public health problem, and is the most common type of cancer observed in Caucasians. The three most common forms of skin cancer are basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and melanoma. BCC and SCC are together known as non-melanoma skin cancers (NMSC), and are both derived from keratino‐cytes whereas melanomas are derived from melanocytes. SCCs can undergo metastasis; BCCs rarely do,...

Cancer cachexia, is a syndrome characterized by weight loss, anorexia and malnutrition, which has been shown in about 50%-80% of cancer patients and accounts for 20% of the causes cancer-related mortality. IL-6 (Interukin-6) is an inflammatory factor shown frequently in cancer cachexia patients. The aim of our study was to investigate the association between IL-6 and nutritional status in metastatic cancer patients.

Background: There is limited supporting evidence for proton radiotherapy in non-small cell lung cancer (NSCLC). Thoracic proton radiotherapy research is required.Trial rationale: Standard of care for unresectable stage III NSCLC in PS0-1 is concurrent chemoradiotherapy (cCTRT) + durvalumab. Durvalumab improves median OS: 28.3 vs 16.2 months; P=0.005. Lymphopenia & cardiac toxicity post RT in NSCLC = poor OS. Proton RT could spare the heart and lead...

An increasing number of patients with cancer are being shifted from inpatient care to outpatient care. However, psychosocial care needs tend to be neglected in oncology outpatient settings. ObjectivesThis study aimed to (i) examine the prevalence and severity of anxiety and depression in female patients with cancer being treated in outpatient settings in Taiwan and (ii) identify factors related to anxiety and depression.Methods and MaterialsA cross-sectional...

ObjectivesPrimary vaginal carcinomas are rare, accounting for 1-2% of gynaecological malignancies. This project aimed to describe a series of primary vaginal cancer cases at a single institution, identifying patient, tumour and treatment factors impacting outcomes. MethodsA retrospective chart analysis was performed for all patients diagnosed with primary vaginal cancer from 2008 to 2018 at a single institution in Australia. For each case, data extracted...

Introducion: Our purpose was to analyse the Overall Survival (OS) and Disease-Free Survival (DFS) comparing subgrous with different tumor spread pattern.Methodology: A total of 118 patients with primary ovarian cancer who received complete cytoreductive surgery were included in current retrospective analysis. Mean age was 57 years (18-90). The histologic type most common was high grade serous carcinoma (48.6%). According to FIGO staging, patients...